Synthesis of Fluphenazine Decanoate using Candida Antarctica Lipase B Enzyme
Sachika Tomer
Navrachana International School, Vadodara, Gujarat, India
Dhirsinh Rathod
Nia Innovation LLP, Vadodara, Gujarat, India
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http://doi.org/10.37648/ijps.v18i01.007
Abstract
In the present work, we have synthesized Fluphenazine Decanoate by using easily available starting materials like Fluphenazine, Decanoic acid and Lipase B Candida antarctica CALB enzyme. The process avoids the use of Decanoyl chloride which in turn is synthesized from Decanoic acid and toxic as well as corrosive chemicals, like thionyl chloride. This process is green and atom economic as compared to the other reported processes till date. Fluphenazine decanoate synthesized by this process is enough pure (purity 99.6%) for subsequent uses. The synthesized product is characterized by using HPLC, NMR and Mass spectroscopy.
Keywords:
Green synthesis; Fluphenazine decanoate; Lipase B Candida antarctica CALB; Esterification; Recycling of CALB
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